甲基强的松龙冲击疗法治疗非肾性红斑狼疮
Methylprednisolone pulse therapy for nonrenal lupus erythematosus.
作者信息
Eyanson S, Passo M H, Aldo-Benson M A, Benson M D
出版信息
Ann Rheum Dis. 1980 Aug;39(4):377-80. doi: 10.1136/ard.39.4.377.
Abstract
High-dose intravenous methylprednisolone therapy has previously been shown to be efficacious in the treatment of renal lupus erythematosus. The present report presents 2 patients with life-threatening, nonrenal lupus erythematosus. One patient had coma and seizures, while the other had sever thrombocytopenia and anaemia. Both had failed to respond to oral corticosteroid therapy in high doses but had dramatic clinical responses with intravenous methylprednisolone given in 'pulses.' Possible mechanisms of clinical improvement are discussed.
摘要
大剂量静脉注射甲基强的松龙疗法先前已被证明在治疗肾性红斑狼疮中有效。本报告介绍了2例患有危及生命的非肾性红斑狼疮的患者。1例患者出现昏迷和癫痫发作，另1例有严重血小板减少和贫血。两人对高剂量口服皮质类固醇疗法均无反应，但静脉注射“脉冲式”甲基强的松龙后有显著临床反应。文中讨论了临床改善的可能机制。
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