Shoemaker Trevor, Boulianne Carla, Vincent Martin J, Pezzanite Linda, Al-Qahtani Mohammed M, Al-Mazrou Yagub, Khan Ali S, Rollin Pierre E, Swanepoel Robert, Ksiazek Thomas G, Nichol Stuart T
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Emerg Infect Dis. 2002 Dec;8(12):1415-20. doi: 10.3201/eid0812.020195.
The first confirmed Rift Valley fever outbreak outside Africa was reported in September 2000, in the Arabian Peninsula. As of February 2001, a total of 884 hospitalized patients were identified in Saudi Arabia, with 124 deaths. In Yemen, 1,087 cases were estimated to have occurred, with 121 deaths. Laboratory diagnosis of Rift Valley fever virus (RVFV) infections included virus genetic detection and characterization of clinical specimens by reverse transcription-polymerase chain reaction, in addition to serologic tests and virus isolation. Genetic analysis of selected regions of virus S, M, and L RNA genome segments indicated little genetic variation among the viruses associated with disease. The Saudi Arabia and Yemen viruses were almost identical to those associated with earlier RVF epidemics in East Africa. Analysis of S, M, and L RNA genome segment sequence differences showed similar phylogenetic relationships among these viruses, indicating that genetic reassortment did not play an important role in the emergence of this virus in the Arabian Peninsula. These results are consistent with the recent introduction of RVFV into the Arabian Peninsula from East Africa.
2000年9月，阿拉伯半岛报告了非洲以外首次确诊的裂谷热疫情。截至2001年2月，沙特阿拉伯共确诊884例住院患者，其中124人死亡。据估计，也门发生了1087例病例，121人死亡。裂谷热病毒（RVFV）感染的实验室诊断包括通过逆转录-聚合酶链反应对临床标本进行病毒基因检测和特征分析，此外还包括血清学检测和病毒分离。对病毒S、M和L RNA基因组片段选定区域的基因分析表明，与疾病相关的病毒之间几乎没有基因变异。沙特阿拉伯和也门的病毒与东非早期裂谷热疫情相关的病毒几乎相同。对S、M和L RNA基因组片段序列差异的分析表明，这些病毒之间具有相似的系统发育关系，这表明基因重配在该病毒在阿拉伯半岛出现过程中未发挥重要作用。这些结果与裂谷热病毒近期从东非传入阿拉伯半岛的情况一致。
