在需氧和厌氧条件下利奈唑胺对耐甲氧西林金黄色葡萄球菌和耐万古霉素粪肠球菌活性的比较。
Comparison of linezolid activities under aerobic and anaerobic conditions against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.
作者信息
Gunderson Brent W, Ibrahim Khalid H, Peloquin Charles A, Hovde Laurie B, Rotschafer John C
机构信息
Department of Experimental and Clinical Pharmacology, The University of Minnesota College of Pharmacy, Minneapolis, Minnesota 55455, USA.
出版信息
Antimicrob Agents Chemother. 2003 Jan;47(1):398-9. doi: 10.1128/AAC.47.1.398-399.2003.
Abstract
Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium were exposed to linezolid (MIC of 2 mg/liter) under aerobic or anaerobic conditions in an in vitro pharmacodynamic model. Drug concentration and half-life were adjusted to simulate clinical dosing (600 mg twice daily) of linezolid. Linezolid produced a 2-log(10) killing at 24 h, and rates of killing against each of these facultative organisms as measured by mean survival time appeared similar under aerobic and anaerobic conditions.
摘要
在体外药效学模型中，耐甲氧西林金黄色葡萄球菌和耐万古霉素粪肠球菌在有氧或无氧条件下暴露于利奈唑胺（最低抑菌浓度为2毫克/升）。调整药物浓度和半衰期以模拟利奈唑胺的临床给药方案（每日两次，每次600毫克）。利奈唑胺在24小时时产生了2个对数（10）的杀菌效果，并且通过平均存活时间测量，在有氧和无氧条件下对这些兼性菌的杀菌速率似乎相似。
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