将HMR 3787和RU 64399与其他四种药物针对流感嗜血杆菌和副流感嗜血杆菌的活性进行比较。
Activities of HMR 3787 and RU 64399 compared with those of four other agents against Haemophilus influenzae and Haemophilus parainfluenzae.
作者信息
Bozdogan Bülent, Clark Catherine, Bryskier Andre, Jacobs Michael R, Appelbaum Peter C
机构信息
Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
出版信息
Antimicrob Agents Chemother. 2003 Jan;47(1):405-7. doi: 10.1128/AAC.47.1.405-407.2003.
Abstract
Activities of HMR 3787, a new 2-fluoroketolide, and its (des)-fluor derivative, RU 64399, were tested against 111 Haemophilus influenzae and 26 H. parainfluenzae strains and compared with those of telithromycin, erythromycin, azithromycin, and clarithromycin. HMR 3787 and RU 64399 MICs were comparable with those of azithromycin but were less affected by incubation in CO(2). Time-kill studies of 12 strains showed that HMR 3787, RU 64399, and telithromycin were bactericidal against all strains after 24 h at two times the MIC.
摘要
对新型2-氟酮内酯类药物HMR 3787及其（去）氟衍生物RU 64399针对111株流感嗜血杆菌和26株副流感嗜血杆菌进行了活性测试，并与泰利霉素、红霉素、阿奇霉素和克拉霉素进行了比较。HMR 3787和RU 64399的最低抑菌浓度（MIC）与阿奇霉素相当，但在二氧化碳环境中孵育时受影响较小。对12株菌株的时间杀菌研究表明，HMR 3787、RU 64399和泰利霉素在两倍MIC浓度下作用24小时后对所有菌株均有杀菌作用。
相似文献
1
Activities of HMR 3787 and RU 64399 compared with those of four other agents against Haemophilus influenzae and Haemophilus parainfluenzae.将HMR 3787和RU 64399与其他四种药物针对流感嗜血杆菌和副流感嗜血杆菌的活性进行比较。
Antimicrob Agents Chemother. 2003 Jan;47(1):405-7. doi: 10.1128/AAC.47.1.405-407.2003.
2
Activities of two novel macrolides, GW 773546 and GW 708408, compared with those of telithromycin, erythromycin, azithromycin, and clarithromycin against Haemophilus influenzae.两种新型大环内酯类药物GW 773546和GW 708408与泰利霉素、红霉素、阿奇霉素及克拉霉素相比，对流感嗜血杆菌的抗菌活性。
Antimicrob Agents Chemother. 2004 Nov;48(11):4113-9. doi: 10.1128/AAC.48.11.4113-4119.2004.
3
Activity of HMR 3647 compared to those of five agents against Haemophilus influenzae and moraxella catarrhalis by MIC determination and time-kill assay.通过最低抑菌浓度（MIC）测定和时间-杀菌试验，比较HMR 3647与五种药物对流感嗜血杆菌和卡他莫拉菌的活性。
Antimicrob Agents Chemother. 1998 Nov;42(11):3032-4. doi: 10.1128/AAC.42.11.3032.
4
Activities of a new fluoroketolide, HMR 3787, and its (des)-fluor derivative RU 64399 compared to those of telithromycin, erythromycin A, azithromycin, clarithromycin, and clindamycin against macrolide-susceptible or -resistant Streptococcus pneumoniae and S. pyogenes.一种新型氟酮内酯类药物HMR 3787及其（去）氟衍生物RU 64399，与泰利霉素、红霉素A、阿奇霉素、克拉霉素和克林霉素相比，对大环内酯类敏感或耐药的肺炎链球菌和化脓性链球菌的活性。
Antimicrob Agents Chemother. 2001 Nov;45(11):3242-5. doi: 10.1128/AAC.45.11.3242-3245.2001.
5
In vitro activity of telithromycin against Haemophilus influenzae at epithelial lining fluid concentrations.泰利霉素在上皮衬液浓度下对流感嗜血杆菌的体外活性。
BMC Microbiol. 2008 Jan 29;8:23. doi: 10.1186/1471-2180-8-23.
6
Comparative antimicrobial activity and kill-curve investigations of novel ketolide antimicrobial agents (HMR 3004 and HMR 3647) tested against Haemophilus influenzae and Moraxella catarrhalis strains.新型酮内酯类抗菌剂（HMR 3004和HMR 3647）对流感嗜血杆菌和卡他莫拉菌菌株的抗菌活性比较及杀菌曲线研究。
Diagn Microbiol Infect Dis. 1998 Jun;31(2):349-53. doi: 10.1016/s0732-8893(98)00022-4.
7
[in vitro activity of telithromycin against Haemophilus influenzae].[泰利霉素对流感嗜血杆菌的体外活性]
Pathol Biol (Paris). 2002 Feb;50(1):58-62. doi: 10.1016/s0369-8114(01)00269-3.
8
In-vitro activity of HMR 3647 against Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and beta-haemolytic streptococci.HMR 3647对肺炎链球菌、流感嗜血杆菌、卡他莫拉菌和β溶血性链球菌的体外活性。
J Antimicrob Chemother. 1999 Oct;44(4):445-53. doi: 10.1093/jac/44.4.445.
9
Influence of variations in test methods on susceptibility of Haemophilus influenzae to ampicillin, azithromycin, clarithromycin, and telithromycin.检测方法的差异对流感嗜血杆菌对氨苄西林、阿奇霉素、克拉霉素和泰利霉素敏感性的影响。
J Clin Microbiol. 2001 Jan;39(1):43-6. doi: 10.1128/JCM.39.1.43-46.2001.
10
In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides against Streptococcus pneumoniae and Haemophilus influenzae.新型酮内酯类药物HMR 3004与氮杂内酯类和大环内酯类药物相比，对肺炎链球菌和流感嗜血杆菌的体外活性。
Eur J Clin Microbiol Infect Dis. 1997 Oct;16(10):767-9. doi: 10.1007/BF01709263.
本文引用的文献
1
Activities of a new fluoroketolide, HMR 3787, and its (des)-fluor derivative RU 64399 compared to those of telithromycin, erythromycin A, azithromycin, clarithromycin, and clindamycin against macrolide-susceptible or -resistant Streptococcus pneumoniae and S. pyogenes.一种新型氟酮内酯类药物HMR 3787及其（去）氟衍生物RU 64399，与泰利霉素、红霉素A、阿奇霉素、克拉霉素和克林霉素相比，对大环内酯类敏感或耐药的肺炎链球菌和化脓性链球菌的活性。
Antimicrob Agents Chemother. 2001 Nov;45(11):3242-5. doi: 10.1128/AAC.45.11.3242-3245.2001.
2
Overcoming antimicrobial resistance: profile of a new ketolide antibacterial, telithromycin.克服抗菌药物耐药性：新型酮内酯类抗菌药物泰利霉素简介
J Antimicrob Chemother. 2001 Sep;48 Suppl T1:9-23. doi: 10.1093/jac/48.suppl_2.9.
3
Association of amino acid substitutions in penicillin-binding protein 3 with beta-lactam resistance in beta-lactamase-negative ampicillin-resistant Haemophilus influenzae.β-内酰胺酶阴性的氨苄西林耐药流感嗜血杆菌中青霉素结合蛋白3氨基酸替代与β-内酰胺耐药性的关联
Antimicrob Agents Chemother. 2001 Jun;45(6):1693-9. doi: 10.1128/AAC.45.6.1693-1699.2001.
4
Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review.2000年慢性阻塞性肺疾病中的细菌感染：最新综述
Clin Microbiol Rev. 2001 Apr;14(2):336-63. doi: 10.1128/CMR.14.2.336-363.2001.
5
Ketolides-telithromycin, an example of a new class of antibacterial agents.酮内酯类——泰利霉素，一类新型抗菌药物的一个实例。
Clin Microbiol Infect. 2000 Dec;6(12):661-9. doi: 10.1046/j.1469-0691.2000.00185.x.
6
Susceptibilities of Haemophilus influenzae and Moraxella catarrhalis to ABT-773 compared to their susceptibilities to 11 other agents.与流感嗜血杆菌和卡他莫拉菌对其他11种药物的敏感性相比，它们对ABT-773的敏感性。
Antimicrob Agents Chemother. 2001 Jan;45(1):67-72. doi: 10.1128/AAC.45.1.67-72.2001.
7
Susceptibilities of Streptococcus pneumoniae and Haemophilus influenzae to 10 oral antimicrobial agents based on pharmacodynamic parameters: 1997 U.S. Surveillance study.基于药效学参数的肺炎链球菌和流感嗜血杆菌对10种口服抗菌药物的敏感性：1997年美国监测研究
Antimicrob Agents Chemother. 1999 Aug;43(8):1901-8. doi: 10.1128/AAC.43.8.1901.
8
Antibacterial activity of RU 64004 (HMR 3004), a novel ketolide derivative active against respiratory pathogens.新型酮内酯衍生物RU 64004（HMR 3004）对呼吸道病原体的抗菌活性
Antimicrob Agents Chemother. 1997 Oct;41(10):2149-58. doi: 10.1128/AAC.41.10.2149.
Zotero 插件