Iniesta Juan A, Corral Javier, González-Conejero Rocio, Piqueras Claudio, Vicente Vicente
Neurosurgery Division, Hospital Virgen de la Arrixaca, Murcia, Spain.
Cerebrovasc Dis. 2003;15(1-2):51-5. doi: 10.1159/000067126.
Several reports suggested that polymorphisms affecting the structure or level of the main adhesive platelet glycoproteins (GPs) could behave as genetic risk factors for arterial thrombotic disorders. However, very few reports analyzed the significance of these polymorphisms in bleeding disorders. Interestingly, one study suggested a role of the 807 C/T polymorphism of the collagen receptor GP Ia in the severity of the bleeding manifestations in von Willebrand disease. The aim of this study was to evaluate the role of frequent polymorphisms affecting platelet GPs in primary intracerebral hemorrhage (PIH), the third most frequent cause of cerebrovascular disorder.
We evaluated the role of four putative prothrombotic polymorphisms: GP Ia [807 C/T, and human platelet alloantigen system 5 (HPA-5)], GP Ibalpha (variable number of tandem repeats), and GP IIIa (HPA-1) in 141 Caucasian patients diagnosed of PIH, 141 race-, age-, sex- and risk factor-matched controls, and 446 subjects from the general population.
The frequency of genotypes and alleles were similar between patients and controls.
Our results suggest that these polymorphisms play a minor role in PIH.
多项报告表明，影响主要黏附性血小板糖蛋白（GPs）结构或水平的多态性可能是动脉血栓形成性疾病的遗传风险因素。然而，极少有报告分析这些多态性在出血性疾病中的意义。有趣的是，一项研究表明，胶原受体GP Ia的807 C/T多态性在血管性血友病出血表现的严重程度中起作用。本研究的目的是评估影响血小板GPs的常见多态性在原发性脑出血（PIH）中的作用，PIH是脑血管疾病的第三大常见病因。
我们评估了四种假定的促血栓形成多态性的作用：GP Ia [807 C/T，以及人类血小板同种抗原系统5（HPA-5）]、GP Ibalpha（串联重复可变数目）和GP IIIa（HPA-1），研究对象包括141例被诊断为PIH的白种人患者、141例种族、年龄、性别和风险因素匹配的对照者，以及446名普通人群。
患者和对照者之间的基因型和等位基因频率相似。
我们的结果表明，这些多态性在PIH中起的作用较小。
