Gonzalez-Conejero R, Lozano M L, Rivera J, Corral J, Iniesta J A, Moraleda J M, Vicente V
Unit of Hematology and Hemotherapy, and the Department of Neurology, School of Medicine. Hospital General Universitario, Murcia, Spain.
Blood. 1998 Oct 15;92(8):2771-6.
Platelet membrane glycoprotein Ibalpha (GPIbalpha) is a major receptor for von Willebrand factor and thrombin, which plays a key role in the initial development of thrombi. Two polymorphisms (HPA-2 and VNTR) that affect phenotype have been described in GPIbalpha. The relevance of these polymorphisms to thrombotic disease was investigated by genotypic identification in three case-control studies: 104 case patients with acute cerebrovascular disease (CVD), 101 case patients with acute coronary heart disease (CHD), 95 patients with deep venous thrombosis (DVT), and one control age-, sex-, and race-matched for each case patient. Results show that the C/B genotype of the VNTR and the HPA-2b polymorphisms of GPIbalpha are strongly associated with increased risk of coronary heart disease and cerebral vascular disease but not with deep vein thrombosis. These two polymorphisms of GPIbalpha may represent newly identified risk factors for arterial thrombotic disease, but not for venous thrombosis.
血小板膜糖蛋白Ibalpha（GPIbalpha）是血管性血友病因子和凝血酶的主要受体，在血栓形成的初始阶段起关键作用。GPIbalpha中已描述了两种影响表型的多态性（HPA-2和VNTR）。在三项病例对照研究中通过基因分型研究了这些多态性与血栓形成疾病的相关性：104例急性脑血管病（CVD）病例患者、101例急性冠心病（CHD）病例患者、95例深静脉血栓形成（DVT）患者，以及为每名病例患者匹配的年龄、性别和种族相同的一名对照。结果显示，VNTR的C/B基因型和GPIbalpha的HPA-2b多态性与冠心病和脑血管病风险增加密切相关，但与深静脉血栓形成无关。GPIbalpha的这两种多态性可能代表新发现的动脉血栓形成疾病风险因素，但不是静脉血栓形成的风险因素。
