Kozer Eran, Nikfar Shekoufeh, Costei Adriana, Boskovic Rada, Nulman Irena, Koren Gideon
Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Onatario, Canada.
Am J Obstet Gynecol. 2002 Dec;187(6):1623-30. doi: 10.1067/mob.2002.127376.
The purpose of this study was to determine, on the basis of published reports, whether aspirin use during the first trimester of pregnancy is associated with an increased risk of congenital malformations.
We reviewed the literature for published studies that reported exposure to aspirin during the first trimester of pregnancy and congenital malformations. Two reviewers independently determined whether a study should be included in the final analysis and extracted the data. We calculated the pooled odds ratio and 95% CI.
Twenty-two studies met the inclusion criteria. In the eight studies that reported an overall risk, the risk of congenital malformations in offspring of women who were exposed to aspirin was not significantly higher than that in control subjects (odds ratio, 1.33; 95% CI, 0.94-1.89). However, a significantly increased risk of gastroschisis (odds ratio, 2.37; 95% CI, 1.44-3.88) was found.
We found no evidence of an overall increase in the risk of congenital malformations that could be associated with aspirin. Aspirin exposure during the first trimester may be associated with an increased risk of gastroschisis.
本研究旨在根据已发表的报告，确定孕期头三个月使用阿司匹林是否会增加先天性畸形的风险。
我们检索了文献中报告孕期头三个月接触阿司匹林与先天性畸形情况的已发表研究。两名审阅者独立判定一项研究是否应纳入最终分析并提取数据。我们计算了合并比值比及95%置信区间。
22项研究符合纳入标准。在8项报告总体风险的研究中，接触阿司匹林的女性所生后代出现先天性畸形的风险并不显著高于对照组（比值比为1.33；95%置信区间为0.94 - 1.89）。然而，发现腹裂风险显著增加（比值比为2.37；95%置信区间为1.44 - 3.88）。
我们没有发现阿司匹林会使先天性畸形总体风险增加的证据。孕期头三个月接触阿司匹林可能与腹裂风险增加有关。
