Department of Internal Medicine, Discipline of Clinical Practical Skills, "Victor Babes" University of Medicine and Pharmacy, No. 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
Advanced Cardiology and Hemostaseology Research Center, "Victor Babes" University of Medicine and Pharmacy, No. 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
Medicina (Kaunas). 2022 May 23;58(5):692. doi: 10.3390/medicina58050692.
Thrombophilia is a genetic predisposition to hypercoagulable states caused by acquired haemostasis conditions; pregnancy causes the haemostatic system to become hypercoagulable, which grows throughout the pregnancy and peaks around delivery. Genetic testing for thrombophilic gene mutations is evaluated using different methodologies of real-time polymerase chain reaction and DNA microarrays of specific genes. Adapting the general care of the pregnant woman to the particularities caused by thrombophilia is an important component, so screening is preferred to assess the degree of genetic damage that manifests itself as a risk of thrombosis. The major goal of this narrative review was to quantitatively evaluate the literature data on the specific care of pregnant women with thrombophilia that are at risk of developing unplanned miscarriages.
血栓形成倾向是由获得性止血条件引起的高凝状态的遗传易感性；妊娠使止血系统变得高凝，这种状态在整个妊娠期间逐渐增加，并在分娩时达到峰值。血栓形成倾向基因突变的基因检测使用实时聚合酶链反应和特定基因的 DNA 微阵列的不同方法进行评估。使孕妇的一般护理适应血栓形成倾向引起的特殊性是一个重要组成部分，因此筛查更受欢迎，以评估表现为血栓形成风险的遗传损伤程度。本叙述性综述的主要目的是定量评估关于有发生意外流产风险的血栓形成倾向孕妇的特定护理的文献数据。
