Li L
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050.
Sheng Li Ke Xue Jin Zhan. 1998 Jan;29(1):35-8.
Oxidative stress may play an important role in neuronal degenerative diseases such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. These disorders make the elderly not being able to live normally and move freely. So it is necessary to find effective antioxidants to prevent or cure the aged persons from diseases related to neuronal degeneration. Schisanhenol (Sal) and salvianolic acid A (Sal A) are known antioxidants which were isolated from Chinese herbs respectively. SY-L is a totally synthetic new compound. The results showed that Sal, Sal A and SY-L significantly protect cerebral cells from the injuries induced by oxidative stress.
氧化应激可能在帕金森病、阿尔茨海默病和肌萎缩侧索硬化症等神经退行性疾病中起重要作用。这些疾病使老年人无法正常生活和自由活动。因此，有必要寻找有效的抗氧化剂来预防或治愈老年人与神经退行性变相关的疾病。五味子醇（Sal）和丹酚酸A（Sal A）是分别从中药中分离出的已知抗氧化剂。SY-L是一种完全合成的新化合物。结果表明，Sal、Sal A和SY-L能显著保护脑细胞免受氧化应激诱导的损伤。
