Dujneungkunakorn Taweekiat, Sungkanuparph Somnuek, Vibhagool Asda, Pairoj Wantanit, Chantratita Wasun, Srichunrusami Chutatip, Laothamatas Jiraporn, Pulkes Teeratorn
Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
J Med Assoc Thai. 2002 Oct;85(10):1139-44.
Progressive Multifocal Leukoencephalopathy (PML) is a demyelinating brain disease caused by human polyoma JC virus (JCV). This disease is an important cause of morbidity and mortality in AIDS patients. Definite diagnosis currently requires a brain biopsy. PCR for JCV of CSF, an emerging diagnostic tool, has a high specificity for the diagnosis of PML in patients with characteristics on clinical and neuroradiological findings. The authors report a 36-year-old woman who presented with prolonged fever, progressive weakness, and slow speech for 2 months. Clinical features and MRI findings were compatible with PML. Qualitative PCR for JCV of CSF showed a positive result. This report emphasizes the yield of PCR, the CSF for JCV in a diagnosis of PML, which may reduce the need for a brain biopsy in such cases.
进行性多灶性白质脑病（PML）是一种由人多瘤病毒JC病毒（JCV）引起的脱髓鞘性脑病。该疾病是艾滋病患者发病和死亡的重要原因。目前明确诊断需要进行脑活检。脑脊液JCV的聚合酶链反应（PCR）作为一种新兴的诊断工具，对具有临床和神经影像学特征的患者诊断PML具有高度特异性。作者报告了一名36岁女性，出现持续发热、进行性无力和言语迟缓2个月。临床特征和磁共振成像（MRI）表现与PML相符。脑脊液JCV的定性PCR结果呈阳性。本报告强调了PCR检测脑脊液JCV在PML诊断中的价值，这可能减少此类病例中脑活检的必要性。
