Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei.

作者信息

Sirirath Sodngam, Tanaka Junichi, Ohtani Ikuko I, Ichiba Toshio, Rachmat Rachmaniar, Ueda Kazunori, Usui Takeo, Osada Hiroyuki, Higa Tatsuo

机构信息

Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.

出版信息

J Nat Prod. 2002 Dec;65(12):1820-3. doi: 10.1021/np0200865.

DOI:10.1021/np0200865

PMID:12502321

Abstract

Six new polyketides, bitungolides A-F (1-6), have been isolated from the Indonesian sponge Theonella cf. swinhoei and their structures elucidated by spectroscopic data and X-ray diffraction analysis. The bitungolides are a new class of Theonella metabolites that inhibit dual-specificity phosphatase VHR.

摘要