Hosoe Tomoo, Sakai Hideo, Ichikawa Makoto, Itabashi Takeshi, Ishizaki Takayuki, Kawai Ken-Ichi
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara, Tokyo, Japan.
J Antibiot (Tokyo). 2007 Jun;60(6):388-90. doi: 10.1038/ja.2007.53.
In the course of screening for hyaluronidase (HAase) inhibitory agents, a new gamma-pyrone derivative, lepidepyrone, C(8)H(10)O(5), was isolated from the cultured mycelium of the mushroom Neolentinus lepideus TMC-1102 as a major HAase inhibitory compound (IC(50) 3.3 mM). The structure of lepidepyrone was established on the basis of spectroscopic investigation.
在筛选透明质酸酶（HAase）抑制剂的过程中，从香菇新香菇TMC-1102的培养菌丝体中分离出一种新的γ-吡喃酮衍生物，lepidepyrone，C(8)H(10)O(5)，作为主要的HAase抑制化合物（IC(50) 3.3 mM）。基于光谱研究确定了lepidepyrone的结构。
