Sönmez Mehmet, Berber Ismet, Akbaş Esvet
Department of Chemistry, Faculty of Science and Arts, Yüzüncü Yil University, 65080 Van, Turkey.
Eur J Med Chem. 2006 Jan;41(1):101-5. doi: 10.1016/j.ejmech.2005.10.003. Epub 2005 Nov 15.
The new various metal complexes of 5-benzoyl-4-hydroxy-2-methyl-6-phenyl-2H-pyridazin-3-one were synthesized. All the complexes were evaluated for their antimicrobial activities against Gram-positive, Gram-negative bacteria and fungi using microdilution procedure. The Cd(II) and Ni(II) complexes exhibited selective and effective activities against one Gram-positive bacterium (Staphylococcus aureus ATCC 6538), one Gram-negative bacterium (Pseudomonas putida ATCC 12633) and against two yeast (Candida albicans ATCC 27541 and Candida tropicalis 1828) in contrast to poor activity observed other microorganisms. The new synthesized complexes were characterized using IR, 1H-NMR and UV spectral data together with elemental analysis.
合成了新型的5-苯甲酰基-4-羟基-2-甲基-6-苯基-2H-哒嗪-3-酮的各种金属配合物。采用微量稀释法对所有配合物针对革兰氏阳性菌、革兰氏阴性菌和真菌的抗菌活性进行了评估。与对其他微生物观察到的较差活性相比，镉（II）和镍（II）配合物对一种革兰氏阳性菌（金黄色葡萄球菌ATCC 6538）、一种革兰氏阴性菌（恶臭假单胞菌ATCC 12633）以及两种酵母（白色念珠菌ATCC 27541和热带念珠菌1828）表现出选择性和有效的活性。利用红外光谱、1H-核磁共振光谱和紫外光谱数据以及元素分析对新合成的配合物进行了表征。
