Tukaev S V, Vesel'skiĭ S P, Reshetnik E N, Liashchenko P S
Kiev National University, 64 Volodimirska St., 01033 Kiev, Ukraine.
Ross Fiziol Zh Im I M Sechenova. 2002 Aug;88(8):1010-6.
Verapamil was studied for its effects on secretory function of liver in rats. In the animals with low initial level of bile secretion, infusion of verapamil resulted in increase of the bile flow conjugated with taurine bile salts and ester of cholesterol, and in reduction of the non-conjugated bile salts secretion, as well as bile salts conjugated with glycine. In the animals with high initial level of the liver secretory function, verapamil decreased the bile flow, the secretion of unconjugated bile salts, and bile salts conjugated with taurine and glycine, phospholipids, cholesterol and its ester. The changes of bile flow and biliary secretion of bile acids and lipids in two groups of animals suggest that verapamil could be influenced in regulation of bile secretion depending on its initial level. Possible mechanisms of the bile secretion regulation by verapamil, are discussed.
研究了维拉帕米对大鼠肝脏分泌功能的影响。在初始胆汁分泌水平较低的动物中，输注维拉帕米导致与牛磺胆酸盐和胆固醇酯结合的胆汁流量增加，非结合胆盐分泌减少，以及与甘氨酸结合的胆盐分泌减少。在肝脏分泌功能初始水平较高的动物中，维拉帕米降低了胆汁流量、非结合胆盐分泌以及与牛磺酸和甘氨酸结合的胆盐、磷脂、胆固醇及其酯的分泌。两组动物胆汁流量以及胆汁酸和脂质的胆汁分泌变化表明，维拉帕米对胆汁分泌的调节可能受其初始水平的影响。文中讨论了维拉帕米调节胆汁分泌的可能机制。
