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我来,我见,我征服——原子分辨率解析蛋白质功能之谜

Veni, vidi, vici - atomic resolution unravelling the mysteries of protein function.

作者信息

Schmidt Andrea, Lamzin Victor S

机构信息

European Molecular Biology Laboratory (EMBL), Hamburg c/o DESY, Notkestrasse 85, Germany.

出版信息

Curr Opin Struct Biol. 2002 Dec;12(6):698-703. doi: 10.1016/s0959-440x(02)00394-9.

Abstract

Atomic resolution macromolecular crystallography has become a powerful and versatile tool in structural biology; the number of atomic resolution structures is steadily increasing. Novel techniques are being developed and the use of complementary methods that span the field from sample preparation to validation and analysis of the resulting models has emerged. These allow the fuller exploitation of the information stored in crystal structures and reveal a depth of structural detail that was unattainable in the recent past.

摘要

原子分辨率大分子晶体学已成为结构生物学中一种强大且通用的工具;原子分辨率结构的数量在稳步增加。新技术不断涌现,并且出现了从样品制备到所得模型的验证与分析等涵盖该领域的互补方法的应用。这些方法能够更充分地利用晶体结构中存储的信息,并揭示出不久前还无法获得的结构细节深度。

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