孕晚期阴道给药后单硝酸异山梨酯的血清概况。

Serum profile of isosorbide mononitrate after vaginal administration in the third trimester.

作者信息

Bates Catharine D, Nicoll Antony E, Mullen Alexander B, Mackenzie Fiona, Thomson Andrew J, Norman Jane E

机构信息

Department of Pharmaceutical Sciences, University of Strathclyde, UK.

出版信息

BJOG. 2003 Jan;110(1):64-7.

PMID:12504938

Abstract

Vaginally administered nitric oxide donors such as isosorbide mononitrate have been used to ripen the uterine cervix in pregnancy. The pharmacokinetics of isosorbide mononitrate following vaginal administration are unknown. Serum levels of isosorbide mononitrate were determined at baseline and 60, 180 and 360 minutes after vaginal administration of 20 or 40 mg isosorbide mononitrate to pregnant women scheduled for induction of labour at term. Serum levels of isosorbide mononitrate continued to rise up to 360 minutes after isosorbide mononitrate insertion, with mean (SD) final levels of 337 (94) microg/L following isosorbide mononitrate 40 mg and 144 (47) microg/L following isosorbide mononitrate 20 mg, P < 0.01.

摘要

阴道给药的一氧化氮供体，如单硝酸异山梨酯，已被用于妊娠时宫颈的成熟。阴道给药后单硝酸异山梨酯的药代动力学尚不清楚。对足月计划引产的孕妇阴道给予20或40mg单硝酸异山梨酯后，在基线以及给药后60、180和360分钟测定血清中单硝酸异山梨酯的水平。单硝酸异山梨酯插入后血清水平持续上升至360分钟，单硝酸异山梨酯40mg后的平均（标准差）最终水平为337（94）μg/L，单硝酸异山梨酯20mg后的平均（标准差）最终水平为144（47）μg/L，P<0.01。