Ekerhovd Erling, Bullarbo Maria, Andersch Björn, Norström Anders
Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.
Am J Obstet Gynecol. 2003 Dec;189(6):1692-7. doi: 10.1016/s0002-9378(03)00865-2.
Our aim was to examine the effect of the nitric oxide donor isosorbide mononitrate on the uterine cervix at term and to evaluate possible adverse effects of this treatment.
Term pregnant women were randomly selected to receive either 40 mg vaginally administered isosorbide mononitrate or placebo 4 hours before elective cesarean section. Cervical status, maternal blood pressure, maternal pulse rate, fetal heart rate, umbilical arterial Doppler indices, and various side effects were examined.
Isosorbide mononitrate induced a significant increase in cervical distensibility. It also caused a significant change in maternal blood pressure and maternal pulse rate. In addition, the frequency of maternal headache and palpitations was significantly higher in the isosorbide mononitrate group versus the placebo group. However, the intensity of these symptoms was moderate.
Vaginal administration of 40 mg of isosorbide mononitrate induces cervical ripening at term. Although the majority of women experienced side effects, no serious clinical maternal or fetal adverse effects, resulting in specific medication or emergency cesarean section, were diagnosed.
我们的目的是研究一氧化氮供体单硝酸异山梨酯对足月子宫颈的影响，并评估该治疗可能产生的不良反应。
在择期剖宫产术前4小时，随机选择足月孕妇阴道给予40mg单硝酸异山梨酯或安慰剂。检查宫颈状况、产妇血压、产妇脉搏率、胎儿心率、脐动脉多普勒指数及各种副作用。
单硝酸异山梨酯可显著增加宫颈扩张性。它还会引起产妇血压和产妇脉搏率的显著变化。此外，单硝酸异山梨酯组产妇头痛和心悸的发生率显著高于安慰剂组。然而，这些症状的强度为中度。
阴道给予40mg单硝酸异山梨酯可使足月宫颈成熟。虽然大多数女性出现了副作用，但未诊断出导致特定药物治疗或急诊剖宫产的严重临床产妇或胎儿不良反应。
