Tanimoto K, Imada M, Ohno S, Sasaki A, Honda K, Tanne K
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
J Dent Res. 2003 Jan;82(1):28-32. doi: 10.1177/154405910308200107.
Pyridinoline (Pyr) and deoxypyridinoline (Dpyr) are intermolecular cross-links of mature collagen and reflect the bone turnover. The purpose of this study was to elucidate the association between craniofacial growth and urinary Pyr and Dpyr levels. Lateral cephalograms and 24-hour urine were taken for 7 male rats from 5 to 20 wks old. The urinary Pyr and Dpyr were quantified by high-performance liquid chromatography. The neurocranium and upper viscerocranium exhibited significant increases in size, with the maximum rate at around 6 wks old. The mandible presented more substantial growth, with the maximum change at 8 wks old. The urinary Pyr and Dpyr levels gradually increased and reached the maximum at 8 wks old. No prominent association was found between neurocranial growth and urinary levels of pyridinium cross-links, whereas Pyr and Dpyr levels exhibited similar time-dependent metabolic changes to mandibular growth. In conclusion, it is shown that urinary pyridinium cross-links may be useful for the prediction of mandibular growth.
吡啶啉（Pyr）和脱氧吡啶啉（Dpyr）是成熟胶原蛋白的分子间交联物，反映骨转换情况。本研究的目的是阐明颅面生长与尿中Pyr和Dpyr水平之间的关联。对7只5至20周龄的雄性大鼠拍摄头颅侧位片并收集24小时尿液。通过高效液相色谱法定量尿中的Pyr和Dpyr。脑颅和上颌面颅骨大小显著增加，最大增长率出现在6周龄左右。下颌骨生长更为显著，最大变化出现在8周龄。尿中Pyr和Dpyr水平逐渐升高，在8周龄时达到最大值。未发现脑颅生长与尿中吡啶鎓交联物水平之间有显著关联，而Pyr和Dpyr水平与下颌骨生长呈现相似的时间依赖性代谢变化。总之，研究表明尿中吡啶鎓交联物可能有助于预测下颌骨生长。
