百草枯诱导的肺损伤对大鼠肺脏药物通透性的影响。

Effect of paraquat-induced lung damage on permeability of rat lung to drugs.

作者信息

Gardiner T H, Schanker L S

出版信息

Proc Soc Exp Biol Med. 1976 Feb;151(2):288-92. doi: 10.3181/00379727-151-39194.

Abstract

To investigate the effect of paraquat-induced lung damage on pulmonary absorption of drugs, rats were given a single oral dose of paraquat (250 mg/kg), and rates of drug absorption from damaged and control lungs were compared after various times. To measure absorption rates of drugs, 0.1 ml of 10 mM drug solution was administered through a tracheal cannula to anesthetized animals and, after various times, lungs were assayed for unabsorbed compound. Drugs investigated were procaine amide ethobromide, p-aminohippuric acid, and procaine amide. Rates of drug absorption increased 1.4-2.8-fold at 3.5 days after paraquat administration and returned to near control values by the 15th day. The results suggest that paraquat-induced lung damage increases the porosity of the pulmonary epithelium.

摘要

为研究百草枯诱导的肺损伤对药物肺部吸收的影响，给大鼠单次口服百草枯（250毫克/千克），并在不同时间后比较受损肺和对照肺的药物吸收速率。为测定药物吸收速率，将0.1毫升10毫摩尔/升的药物溶液通过气管插管给予麻醉动物，在不同时间后，对肺中未吸收的化合物进行测定。所研究的药物有普鲁卡因酰胺乙溴化物、对氨基马尿酸和普鲁卡因酰胺。在给予百草枯后3.5天，药物吸收速率增加了1.4至2.8倍，并在第15天恢复到接近对照值。结果表明，百草枯诱导的肺损伤增加了肺上皮的孔隙率。