可的松对新生大鼠肺脏药物通透性的影响。

Effect of cortisone on permeability of the neonatal rat lung to drugs.

作者信息

Hemberger J A, Schanker L S

出版信息

Biol Neonate. 1981;40(1-2):99-104. doi: 10.1159/000241477.

Abstract

The effect of cortisone (5 mg/animal i.p. on day 5 after birth) on the development of adult-type permeability characteristics in the lung was investigated in rats 6-18 days of age. In both treated and control rats, the lipid-soluble drug procainamide was absorbed at similar rates in all age groups. In contrast, in cortisone-treated animals, pulmonary absorption rates for the lipid-insoluble compounds mannitol and p-aminohippuric acid declined to adult levels at the age of 6 days, which was 12 days earlier than in controls. Cortisone treatment thus accelerates development of adult permeability characteristics in the pulmonary epithelium.

摘要

研究了可的松（出生后第5天腹腔注射5毫克/只动物）对6至18日龄大鼠肺中成人型通透性特征发育的影响。在治疗组和对照组大鼠中，脂溶性药物普鲁卡因酰胺在所有年龄组中的吸收速率相似。相比之下，在接受可的松治疗的动物中，脂溶性化合物甘露醇和对氨基马尿酸的肺部吸收率在6日龄时降至成人水平，这比对照组早12天。因此，可的松治疗加速了肺上皮中成人通透性特征的发育。