转移抑制因子会改变癌细胞的信号转导。
Metastasis suppressors alter the signal transduction of cancer cells.
作者信息
Steeg Patricia S
机构信息
Women's Cancers Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
出版信息
Nat Rev Cancer. 2003 Jan;3(1):55-63. doi: 10.1038/nrc967.
Tumour metastasis is a significant contributor to death in cancer patients. Eight metastasis-suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without affecting its tumorigenicity have been identified. These affect important signal-transduction pathways, including mitogen-activated protein kinases, RHO, RAC and G-protein-coupled and tyrosine-kinase receptors. So how might we use this knowledge to improve the treatment of patients with cancer?
肿瘤转移是导致癌症患者死亡的一个重要因素。已经鉴定出八个转移抑制基因，这些基因可在不影响癌细胞系致瘤性的情况下降低其在体内的转移倾向。它们影响重要的信号转导途径，包括丝裂原活化蛋白激酶、RHO、RAC以及G蛋白偶联受体和酪氨酸激酶受体。那么，我们如何利用这些知识来改善癌症患者的治疗呢？
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