Larocca J N, Rodriguez-Gabin A G
Department of Neurology/Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Neurochem Res. 2002 Nov;27(11):1313-29. doi: 10.1023/a:1021667515030.
Intracellular trafficking of membranes plays an essential role in the biogenesis and maintenance of myelin. The requisite proteins and lipids are transported from their sites of synthesis to myelin via vesicles. Vesicle transport is tightly coordinated with synthesis of lipids and proteins. To maintain the structural and functional organization of oligodendrocytes it is essential synchronize the various pathways of vesicle transport and to coordinate vesicle transport with reorganization of cytoskeleton. The systems that regulate the targeting of protein to myelin by vesicle transport are now being described. Here we review the current knowledge of these systems including those involved in (a) protein folding, (b) protein sorting and formation of carrier vesicles, (c) vesicle transport along elements of the cytoskeleton, and (d) vesicle targeting/fusion.
膜的细胞内运输在髓鞘的生物发生和维持中起着至关重要的作用。必需的蛋白质和脂质通过囊泡从其合成部位运输到髓鞘。囊泡运输与脂质和蛋白质的合成紧密协调。为了维持少突胶质细胞的结构和功能组织，同步囊泡运输的各种途径并使囊泡运输与细胞骨架的重组相协调至关重要。目前正在描述通过囊泡运输将蛋白质靶向髓鞘的调节系统。在这里，我们综述了这些系统的当前知识，包括参与（a）蛋白质折叠、（b）蛋白质分选和载体囊泡形成、（c）沿细胞骨架元件的囊泡运输以及（d）囊泡靶向/融合的系统。
