Pecaut Michael J, Nelson Gregory A, Peters Luanne L, Kostenuik Paul J, Bateman Ted A, Morony Sean, Stodieck Louis S, Lacey David L, Simske Steven J, Gridley Daila S
Department of Radiation Medicine, Radiobiology Program, Division of Microbiology and Molecular Genetics, Loma Linda University and Medical Center, Loma Linda, California 92354, USA.
J Appl Physiol (1985). 2003 May;94(5):2085-94. doi: 10.1152/japplphysiol.01052.2002. Epub 2003 Jan 3.
There are several aspects of the spaceflight environment that may lead to changes in immunity: mission-related psychological stress, radiation, and changes in gravity. On December 5, 2001, the space shuttle Endeavor launched for a 12-day mission to examine these effects on C57BL/6 mice for the first time. On their return, assays were performed on the spleen, blood, and bone marrow. In response to flight, there were no significant differences in the general circulating leukocyte proportions. In contrast, there was an increase in splenic lymphocyte percentages, with a corresponding decrease in granulocytes. There was an overall shift in splenic lymphocytes away from T cells toward B cells, and a decrease in the CD4-to-CD8 ratios due to a decrease in T helpers. In contrast, there were proportional increases in bone marrow T cells, with decreases in B cells. Although the blast percentage and count were decreased in flight mice, the CD34(+) population was increased. The data were more consistent with a shift in bone marrow populations rather than a response to changes in the periphery. Many of the results are similar to those using other models. Clearly, spaceflight can influence immune parameters ranging from hematopoiesis to mature leukocyte mechanisms.
与任务相关的心理压力、辐射和重力变化。2001年12月5日，奋进号航天飞机发射执行一项为期12天的任务，首次研究这些因素对C57BL/6小鼠的影响。返回后，对脾脏、血液和骨髓进行了检测。飞行后，一般循环白细胞比例无显著差异。相比之下，脾脏淋巴细胞百分比增加，粒细胞相应减少。脾脏淋巴细胞总体上从T细胞向B细胞转移，由于辅助性T细胞减少，CD4与CD8比值降低。相比之下，骨髓T细胞比例增加，B细胞减少。虽然飞行小鼠的原始细胞百分比和数量减少，但CD34(+)群体增加。数据更符合骨髓群体的转移，而不是对外周变化的反应。许多结果与使用其他模型的结果相似。显然，航天可以影响从造血到成熟白细胞机制的免疫参数。
