Gaignier Fanny, Legrand-Frossi Christine, Stragier Emilien, Mathiot Julianne, Merlin Jean-Louis, Cohen-Salmon Charles, Lanfumey Laurence, Frippiat Jean-Pol
Stress Immunity Pathogens Laboratory, EA7300, Faculty of Medicine, Université de Lorraine, Vandœuvre-lès-Nancy, France.
INSERM UMR894, Centre de Psychiatrie et Neuroscience, Paris, France.
Front Physiol. 2018 May 9;9:514. doi: 10.3389/fphys.2018.00514. eCollection 2018.
During spaceflight, astronauts face radiations, mechanical, and socio-environmental stressors. To determine the impact of chronic socio-environmental stressors on immunity, we exposed adult male mice to chronic unpredictable mild psychosocial and environmental stressors (CUMS model) for 3 weeks. This duration was chosen to simulate a long flight at the human scale. Our data show that this combination of stressors induces an increase of serum IgA, a reduction of normalized splenic mass and tends to reduce the production of pro-inflammatory cytokines, as previously reported during or after space missions. However, CUMS did not modify major splenic lymphocyte sub-populations and the proliferative responses of splenocytes suggesting that these changes could be due to other factors such as gravity changes. Thus, CUMS, which is an easy to implement model, could contribute to deepen our understanding of some spaceflight-associated immune alterations and could be useful to test countermeasures.
在太空飞行期间，宇航员面临辐射、机械以及社会环境应激源。为了确定慢性社会环境应激源对免疫力的影响，我们将成年雄性小鼠暴露于慢性不可预测的轻度心理社会和环境应激源（CUMS模型）下3周。选择这个时长是为了模拟人类尺度的长时间飞行。我们的数据表明，这种应激源组合会导致血清IgA增加、脾脏归一化质量降低，并倾向于减少促炎细胞因子的产生，正如之前在太空任务期间或之后所报道的那样。然而，CUMS并未改变主要的脾脏淋巴细胞亚群以及脾细胞的增殖反应，这表明这些变化可能是由于其他因素，如重力变化。因此，CUMS作为一种易于实施的模型，有助于加深我们对一些与太空飞行相关的免疫改变的理解，并且可能有助于测试应对措施。
