Ichiki A T, Gibson L A, Jago T L, Strickland K M, Johnson D L, Lange R D, Allebban Z
Graduate School of Medicine, University of Tennessee Medical Center at Knoxville, USA.
J Leukoc Biol. 1996 Jul;60(1):37-43. doi: 10.1002/jlb.60.1.37.
The white blood cell (WBC) elements and the bone marrow myeloid progenitor cell populations were analyzed to ascertain adaptation to micro-gravity and subsequent readaptation to 1 G in rats flown on the 14-day Spacelab Life Sciences-2 (SLS-2) mission. Bone marrow cells were harvested from one group of rats killed inflight (FD13) and blood was drawn from three other groups at various times. The WBC level was normal on FD14 with the exception of neutrophilia. On FD13, numbers of colony-forming units-granulocyte (CFU-G), CFU-GM, and CFU-M from flight animals were decreased compared with ground controls when incubated with recombinant rat interleukin-3 (rrIL-3) alone or in combination with recombinant human erythropoietin (rhEpo). On recovery (R + 0), flight rats had decreased numbers of total leukocytes and absolute numbers of lymphocytes and monocytes with elevated neutrophils compared with control rats. They had lower numbers of CD4, CD8, CD2, CD3, and B cells in the peripheral blood but no differences in spleen lymphocytes.
对在为期14天的太空实验室生命科学-2（SLS-2）任务中飞行的大鼠的白细胞（WBC）成分和骨髓髓系祖细胞群体进行了分析，以确定其对微重力的适应性以及随后重新适应1G重力的情况。从一组在飞行中处死的大鼠（FD13）中采集骨髓细胞，并在不同时间从其他三组大鼠中采集血液。除嗜中性粒细胞增多外，FD14时白细胞水平正常。在FD13时，与地面对照组相比，单独用重组大鼠白细胞介素-3（rrIL-3）或与重组人促红细胞生成素（rhEpo）联合孵育时，飞行大鼠的粒细胞集落形成单位（CFU-G）、CFU-GM和CFU-M数量减少。在恢复时（R + 0），与对照大鼠相比，飞行大鼠的总白细胞数量、淋巴细胞和单核细胞的绝对数量减少，嗜中性粒细胞增多。它们外周血中CD4、CD8、CD2、CD3和B细胞的数量较少，但脾脏淋巴细胞无差异。
