Bernstein Jonathan A, Perez Adrienne, Floyd Roger, Bernstein I Leonard
University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0563, USA.
Obstet Gynecol. 2003 Jan;101(1):93-102. doi: 10.1016/s0029-7844(02)02318-9.
To identify an index population of Gulf War couples with burning semen syndrome and to determine whether burning semen syndrome was secondary to seminal plasma hypersensitivity.
Questionnaire surveys, screening laboratory testing for underlying medical disorders, including sexually transmitted diseases and immunoglobulin G and E immunoassays specific for seminal plasma protein, were performed. If subjects met the criteria for seminal plasma hypersensitivity, the Gulf War male veteran's seminal plasma proteins were used to desensitize his female sexual partner.
Eighty-nine percent (188 of 211) of respondents had either personally experienced burning after contact with their own semen or had a sexual partner who had burning after contact with their semen. Asymptomatic female partners (three of five) of Gulf War veterans who exhibited specific immunoglobulin E skin and antibody responses to seminal plasma proteins responded successfully to rapid desensitization. Treatment results were confirmed by a provocative office challenge, consisting of instillation of whole seminal fluid into the female's vaginal vault and, if negative, subsequently by natural coitus.
The results of this study indicate that seminal plasma hypersensitivity may present as burning semen syndrome in a subpopulation of Gulf War couples. Proper screening of Gulf War couples with clinical features of burning semen syndrome should include assessment for seminal plasma hypersensitivity reactions, as seminal plasma protein desensitization may induce remission of burning semen syndrome.
确定患有精液灼烧综合征的海湾战争夫妇的指标人群，并确定精液灼烧综合征是否继发于精浆超敏反应。
进行问卷调查，对包括性传播疾病在内的潜在医学疾病进行筛查实验室检测，以及针对精浆蛋白的免疫球蛋白G和E免疫测定。如果受试者符合精浆超敏反应的标准，则使用海湾战争男性退伍军人的精浆蛋白对其女性性伴侣进行脱敏治疗。
89%（211名中的188名）的受访者要么亲自经历过接触自身精液后的灼烧感，要么有性伴侣在接触其精液后出现灼烧感。对精浆蛋白表现出特异性免疫球蛋白E皮肤和抗体反应的海湾战争退伍军人的无症状女性伴侣（5名中的3名）对快速脱敏治疗反应成功。治疗结果通过激发性门诊挑战得到证实，包括将全精液滴入女性阴道穹窿，如果结果为阴性，则随后通过自然性交进行。
本研究结果表明，在一部分海湾战争夫妇中，精浆超敏反应可能表现为精液灼烧综合征。对具有精液灼烧综合征临床特征的海湾战争夫妇进行适当筛查应包括评估精浆超敏反应，因为精浆蛋白脱敏可能会使精液灼烧综合征得到缓解。
