阴道液中抗阴道加德纳菌溶血素、唾液酸酶和脯氨酰肽酶活性的免疫球蛋白A测定：对不良妊娠结局的影响
Determination of immunoglobulin A against Gardnerella vaginalis hemolysin, sialidase, and prolidase activities in vaginal fluid: implications for adverse pregnancy outcomes.
作者信息
Cauci Sabina, Thorsen Poul, Schendel Diana E, Bremmelgaard Annie, Quadrifoglio Franco, Guaschino Secondo
机构信息
Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Italy.
出版信息
J Clin Microbiol. 2003 Jan;41(1):435-8. doi: 10.1128/JCM.41.1.435-438.2003.
Abstract
A nested case-control study of low birth weight and preterm delivery was performed with singleton women. Immunoglobulin A (IgA) against the Gardnerella vaginalis hemolysin (anti-Gvh IgA) and sialidase and prolidase activities were determined in vaginal fluid at 17 weeks of gestation. Sialidase positivity and bacterial vaginosis with high prolidase activity were associated with 2- and 11-fold increased risks for low birth weight, respectively. No woman with bacterial vaginosis plus a strong anti-Gvh IgA response had an adverse outcome.
摘要
对单胎妊娠女性进行了一项关于低出生体重和早产的巢式病例对照研究。在妊娠17周时测定阴道分泌物中抗阴道加德纳菌溶血素的免疫球蛋白A（抗Gvh IgA）以及唾液酸酶和脯氨肽酶活性。唾液酸酶阳性以及脯氨肽酶活性高的细菌性阴道病分别与低出生体重风险增加2倍和11倍相关。没有细菌性阴道病且抗Gvh IgA反应强烈的女性出现不良结局。
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