阴道水解酶、抗阴道加德纳菌毒素的免疫球蛋白A以及细菌性阴道病或中间型菌群的早产临产妇女早期早产风险
Vaginal hydrolytic enzymes, immunoglobulin A against Gardnerella vaginalis toxin, and risk of early preterm birth among women in preterm labor with bacterial vaginosis or intermediate flora.
作者信息
Cauci Sabina, Hitti Jane, Noonan Carolyn, Agnew Kathy, Quadrifoglio Franco, Hillier Sharon L, Eschenbach David A
机构信息
Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Udine, Italy.
出版信息
Am J Obstet Gynecol. 2002 Oct;187(4):877-81. doi: 10.1067/mob.2002.127454.
OBJECTIVE
The purpose of this study was to determine whether the microbial hydrolytic enzymes, sialidase and prolidase, and immunoglobulin A against the Gardnerella vaginalis cytolysin (anti-Gvh IgA) increase the risk for early preterm birth (< or =34 weeks of gestation) among women with bacterial vaginosis or intermediate flora.
STUDY DESIGN
Two hundred eighteen afebrile women in preterm labor with intact membranes had a vaginal Gram stain performed, and sialidase, prolidase, and anti-Gvh IgA concentrations were determined.
RESULTS
Women with bacterial vaginosis or intermediate flora had significantly higher sialidase and prolidase concentrations than women with normal flora. Among women with bacterial vaginosis or intermediate flora, the women with sialidase had a higher rate of early preterm birth (P =.05). Sialidase had a sensitivity of 43% and specificity of 77% for early preterm birth. Prolidase and anti-Gvh IgA did not predict early preterm birth.
CONCLUSION
Women in preterm labor with bacterial vaginosis or intermediate flora and detectable sialidase are at increased risk of early preterm birth.
目的
本研究旨在确定微生物水解酶（唾液酸酶和脯氨酰肽酶）以及抗阴道加德纳菌溶细胞素的免疫球蛋白A（抗Gvh IgA）是否会增加细菌性阴道病或中间菌群女性发生早期早产（妊娠≤34周）的风险。
研究设计
218名胎膜完整的早产发热女性接受了阴道革兰氏染色，并测定了唾液酸酶、脯氨酰肽酶和抗Gvh IgA的浓度。
结果
患有细菌性阴道病或中间菌群的女性，其唾液酸酶和脯氨酰肽酶浓度显著高于正常菌群女性。在患有细菌性阴道病或中间菌群的女性中，唾液酸酶阳性的女性早期早产发生率更高（P = 0.05）。唾液酸酶对早期早产的敏感性为43%，特异性为77%。脯氨酰肽酶和抗Gvh IgA不能预测早期早产。
结论
患有细菌性阴道病或中间菌群且可检测到唾液酸酶的早产女性发生早期早产的风险增加。
Zotero 插件