Hotson J R, Langston J W
Arch Neurol. 1976 Feb;33(2):141-2. doi: 10.1001/archneur.1976.00500020069012.
Two patients with disulfiram-(Antabuse-)induced encephalopathy exhibited paranoid ideas, disorientation, impaired memory, ataxia, dysarthria, snout and grasp reflexes, and abnormal electroencephalograms. The first patient developed symptoms on two occasions, each time after disulfiram administration. The second patient experienced a generalized seizure followed by fulminant psychosis three weeks after starting disulfiram therapy. Spinal fluid examination in the latter patient revealed a low homovanillic acid (HVA) level. Since disulfiram inhibits dopamine oxidation, disulfiram-induced encephalopathy may be related to excess dopaminergic activity in the central nervous system.
两名患有双硫仑（安塔布司）诱发脑病的患者出现了妄想观念、定向障碍、记忆力减退、共济失调、构音障碍、噘嘴和抓握反射以及异常脑电图。第一名患者两次出现症状，每次都是在服用双硫仑之后。第二名患者在开始双硫仑治疗三周后出现全身性癫痫发作，随后出现暴发性精神病。对后一名患者的脑脊液检查显示高香草酸（HVA）水平较低。由于双硫仑抑制多巴胺氧化，双硫仑诱发的脑病可能与中枢神经系统中多巴胺能活性过高有关。
