Deuschl G, Fogel W, Hahne M, Kupsch A, Müller D, Oechsner M, Sommer U, Ulm G, Vogt T, Volkmann J
Department of Neurology, Christian-Albrechts-Universität Kiel, Niemannsweg 147, 24105 Kiel, Germany.
J Neurol. 2002 Oct;249 Suppl 3:III/36-9. doi: 10.1007/s00415-002-1308-x.
Deep brain simulation (DBS) is a powerful new therapeutic approach for patients with Parkinson's disease. However, patient selection is critical for a valuable therapeutic result. Dopa sensitivity of the target symptoms, severe disability and low neurosurgical risks are among the major criteria for this indication. Other criteria like age or cognition must still be addressed in future prospective studies. The preferred target for DBS in PD is the subthalamic nucleus for various good reasons. However, prospective studies for this procedure are lacking and some clinical problems may be more easily solved with targeting the internal pallidum or the thalamus. Despite major progress in this field, much work remains to be done.
深部脑刺激（DBS）是一种针对帕金森病患者的强有力的新治疗方法。然而，患者选择对于获得有价值的治疗效果至关重要。目标症状的多巴敏感性、严重残疾和低神经外科手术风险是该适应症的主要标准。年龄或认知等其他标准仍有待未来的前瞻性研究解决。由于各种充分的理由，帕金森病中DBS的首选靶点是丘脑底核。然而，缺乏针对该手术的前瞻性研究，并且通过靶向苍白球内部或丘脑，一些临床问题可能更容易解决。尽管该领域取得了重大进展，但仍有许多工作要做。
