[328份血清样本中TTV DNA和TTV IgG的检测]

[Detection of TTV DNA and TTV IgG in 328 serum samples].

作者信息

Ma D, Guo N, Wang H

机构信息

First People's Hospital of Yancheng City, Jiangsu 224001, China.

出版信息

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2001 Mar;15(1):27-30.

PMID:12526298

Abstract

OBJECTIVE

To investigate the prevalence of TT virus(TTV) in a variety of populations in China.

METHODS

TTV DNA and anti TTV IgG were simultaneously tested by PCR and ELISA.

RESULTS

The positive rate of TTV DNA in the samples of 81 normal subjects, 92 blood donors, 123 hepatitis A-G patients and 32 hepatitis non A-G patients were 2.5%, 2.2%, 19.5% and 28.1%, respectively; and anti-TTV IgG was 1.2%, 3.7%, 26.8% and 34.4%, respectively. There were significant differences between the normal and the blood donor group and the hepatitis group; and among multi-infectious cases, the infection rate of TTV with HBV was as high as 75.0%.

CONCLUSION

The investigation indicated that TTV infection was very popular in different groups. Some of the normal and blood donor groups infected with TTV could become healthy carries of virus. And the hepatitis patients were the high risk group. In addition, TTV may be transmitted via other pathways besides blood.

摘要

目的

调查中国不同人群中TTV病毒（TTV）的感染率。

方法

采用PCR和ELISA方法同时检测TTV DNA和抗TTV IgG。

结果

81例正常受试者、92例献血者、123例甲型至庚型肝炎患者及32例非甲至庚型肝炎患者样本中，TTV DNA阳性率分别为2.5%、2.2%、19.5%和28.1%；抗TTV IgG阳性率分别为1.2%、3.7%、26.8%和34.4%。正常组与献血者组、肝炎组之间存在显著差异；在多重感染病例中，TTV与HBV的合并感染率高达75.0%。