西洋参20S-原人参二醇皂苷对犬急性心肌梗死的保护作用
[Protective effect of Panax quinquefolium 20s-proto-panaxdiolsaponins on acute myocardial infarction in dogs].
作者信息
Sui D Y, Yu X F, Qu S C, Lu Z Z, Wang L, Chen M Q
机构信息
Department of Pharmacology, Bethune Medical University, Changchun 130021, Jilin, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2001 Jun;26(6):416-9.
OBJECTIVE
To study the protective effects of Panax quinquefolium 20s-protopanaxdiolsaponins extracted from leaves of P. quinquefolium (PQDS) on acute myocardial infarction(AMI) in dogs.
METHOD
The parameters of myocardial infart size, the serum CK and LDH activity, myocardial metabolism, free radicals and coronary circulation etc were determined by using the model of ligation of LAD in the anaesthetized open-chest dogs.
RESULT
In dogs treated with PQDS(in a dosage of 10 and 20 mg.kg-1 i.v. infusion), the myocardial infarct size, the activity of serum CK, LDH and the contents of serum FFA and LPO were decreased, whereas the activity of serum SOD and GSH-Px increased markedly. At the same time, myocardial blood flow was increased and coronary vascular resistance decreased significantly.
CONCLUSION
PQDS has protective effect on myocardial ischemia by modifying metabolic dysfunction of FFA, inhibiting oxygen free radical mediated peroxidation of membrane lipids, enhancing endogenous antioxidase activity and increasing myocardial blood supply.
目的
研究从西洋参叶中提取的西洋参20S-原人参二醇皂苷（PQDS）对犬急性心肌梗死（AMI）的保护作用。
方法
采用麻醉开胸犬结扎左冠状动脉前降支（LAD）模型，测定心肌梗死面积、血清肌酸激酶（CK）和乳酸脱氢酶（LDH）活性、心肌代谢、自由基及冠脉循环等指标。
结果
给予PQDS（静脉输注剂量为10和20mg·kg-1）治疗的犬，心肌梗死面积、血清CK、LDH活性及血清游离脂肪酸（FFA）和脂质过氧化物（LPO）含量降低，而血清超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）活性显著升高。同时，心肌血流量增加，冠脉血管阻力显著降低。
结论
PQDS通过改善FFA代谢功能障碍、抑制氧自由基介导的膜脂质过氧化、增强内源性抗氧化酶活性及增加心肌血液供应，对心肌缺血具有保护作用。
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