Jones Michael P, Hoffman Seth, Shah Dhiren, Patel Ketan, Ebert Christine C
Division of Gastroenterology and Hepatology, Northwestern University Medical School, Chicago, Illinois 60611-2908, USA.
Am J Physiol Gastrointest Liver Physiol. 2003 Jun;284(6):G896-904. doi: 10.1152/ajpgi.00361.2002. Epub 2003 Jan 15.
Gastric sensation and accommodation are studied by barostat, but this is invasive. The drink test is noninvasive and may provide similar information. We evaluated relationships between drink test, gastric function, symptoms, and psychiatric distress. Controls (73) and functional dyspeptics (FD) (92) were studied using a 5-min water load test (WL5), gastric emptying, and electrogastrography (EGG). Symptoms, quality of life, and psychiatric distress were measured using standardized measures. Controls underwent test-retest of WL5 and comparison of WL5 with 100 ml/min water-based drink test (WL100) or nutrient drink. Controls, FD, and gastroparetics estimated drinking capacity before WL5 using a visual analog scale. WL5 correlated with WL100 (r = 0.7929) but not nutrient drink test (r = 0.1995). WL5 was significantly less in FD than controls, and abnormal WL5 was seen in 46%. In FD, volume to fullness inversely correlated with symptom severity (r =-0.29; P = 0.0154) and WL5 produced more symptoms, particularly nausea. Gastric function was not different between FD with normal or abnormal WL5. Symptoms and psychiatric distress were similar between normal and abnormal WL5 groups, but the abnormal group had significantly poorer quality of life. Controls and gastroparetics had good correlation of estimated and ingested volumes, but FD did not. Versus FD with normal WL5 capacity, FD with impaired drinking capacity have normal gastric function and similar symptoms but poorer quality of life. FD are less able to predict drinking capacity. These data suggest that WL5 identifies FD with intact gastric function but abnormal visceral perception.
胃感觉和容纳功能通过压力传感器进行研究，但这是侵入性的。饮水试验是非侵入性的，可能提供类似的信息。我们评估了饮水试验、胃功能、症状和精神痛苦之间的关系。使用5分钟水负荷试验（WL5）、胃排空和胃电图（EGG）对73名对照组和92名功能性消化不良（FD）患者进行了研究。使用标准化测量方法测量症状、生活质量和精神痛苦。对对照组进行WL5的重测，并将WL5与100毫升/分钟的水基饮料试验（WL100）或营养饮料进行比较。对照组、FD患者和胃轻瘫患者在WL5之前使用视觉模拟量表估计饮水能力。WL5与WL100相关（r = 0.7929），但与营养饮料试验不相关（r = 0.1995）。FD患者的WL5明显低于对照组，46%的患者出现异常WL5。在FD患者中，饱腹感的体积与症状严重程度呈负相关（r = -0.29；P = 0.0154），WL5产生更多症状，尤其是恶心。WL5正常或异常的FD患者之间胃功能没有差异。正常和异常WL5组之间的症状和精神痛苦相似，但异常组的生活质量明显较差。对照组和胃轻瘫患者估计和摄入的体积具有良好的相关性，但FD患者没有。与WL5能力正常的FD患者相比，饮水能力受损的FD患者胃功能正常，症状相似，但生活质量较差。FD患者预测饮水能力的能力较差。这些数据表明，WL5可识别胃功能正常但内脏感觉异常的FD患者。
