Kilton L J, Aschenbrener C, Burns C P
Cancer. 1976 Feb;37(2):974-83. doi: 10.1002/1097-0142(197602)37:2<974::aid-cncr2820370254>3.0.co;2-g.
Ganglioneuroblastoma is a rare neoplasm of adults. Some information about the natural history and response to therapy can be obtained from two cases seen recently at our hospital and 17 cases in the literature. These tumors occur in adults of any age and are usually located in the retroperitoneum, mediastinum, or neck. Evidence of the tumor may be present years before diagnosis. Elevations of urinary catecholamines were documented in three cases and the levels correlated with progression or resection of the neoplasm. The tumor spreads either by local invasion or distant metastasis. Attempts at radiotherapy and chemotherapy in the treatment of unresectable or disseminated tumor has not resulted in objective improvement. This contrasts with the widely reported objective successes and cures of ganglioneuroblastomas occurring in childhood. Surgical excision of localized disease was the only curative therapeutic modality in the cases we reviewed.
神经节神经母细胞瘤是一种罕见的成人肿瘤。关于其自然病史和对治疗反应的一些信息可从我院最近诊治的2例以及文献报道的17例病例中获取。这些肿瘤可见于任何年龄的成人，通常位于腹膜后、纵隔或颈部。在诊断前数年可能就已存在肿瘤证据。3例患者记录到尿儿茶酚胺升高，且其水平与肿瘤进展或切除相关。肿瘤可通过局部侵犯或远处转移扩散。对于不可切除或播散性肿瘤，放疗和化疗未能带来客观改善。这与广泛报道的儿童神经节神经母细胞瘤的客观成功治愈形成对比。在我们回顾的病例中，手术切除局限性病变是唯一的治愈性治疗方式。
