Gilladoga A C, Manuel C, Tan C T, Wollner N, Sternberg S S, Murphy M L
Cancer. 1976 Feb;37(2 Suppl):1070-8. doi: 10.1002/1097-0142(197602)37:2+<1070::aid-cncr2820370814>3.0.co;2-6.
Eight (16%) of 50 children receiving adriamycin and 2 (3%) of 60 receiving daunomycin had severe cardiomyopathy with congestive heart failure. All 110 patients received cumulative doses of over 500 mg/m2. The incidence was significantly higher in those who also had incidental cardiac radiation. The electrocardiogram, with few exceptions, provided the first indication of cardiac abnormality. There were no deaths from heart failure. Two had thromboembolic episodes. Recommendations are discussed.
50名接受阿霉素治疗的儿童中有8名（16%），60名接受柔红霉素治疗的儿童中有2名（3%）发生了伴有充血性心力衰竭的严重心肌病。所有110名患者接受的累积剂量均超过500mg/m²。在那些同时接受了心脏附带放疗的患者中，发病率显著更高。除少数例外，心电图是心脏异常的首个迹象。没有因心力衰竭导致的死亡。有两名患者发生了血栓栓塞事件。文中讨论了相关建议。
