Hsiung G D, McTighe A H
Cancer Res. 1976 Feb;36(2 pt 2):674-7.
The presence of endogenous oncornavirus and herpesvirus in guinea pigs has been established. The oncornavirus apparently is present in all guinea pigs but is expressed only under certain conditions. Expression of the latent herpesvirus is generally age and strain dependent as is the development of spontaneous guinea pig leukemia. Following special laboratory manipulation, expression of both virus types was accomplished in vitro. Studies of the role played by these two virus types in the development of neoplastic disease in guinea pigs revealed that, in the presence of the endogenous oncornavirus, a superinfection with herpesvirus led to the development of self-limited lymphoproliferative changes. Together with the studies reported by other investigators, it appears that interaction between the DNA and RNA viruses may play an important role in the natural occurrence of viral oncogenesis. Guinea pigs provide an intriguing animal model for the study of herpesvirus and oncornavirus interaction both in vivo and in vitro.
豚鼠体内存在内源性肿瘤病毒和疱疹病毒已得到证实。肿瘤病毒显然存在于所有豚鼠体内，但仅在某些条件下才会表达。潜伏性疱疹病毒的表达通常与年龄和品系有关，自发性豚鼠白血病的发展也是如此。经过特殊的实验室操作，两种病毒类型均在体外实现了表达。对这两种病毒类型在豚鼠肿瘤性疾病发展中所起作用的研究表明，在内源性肿瘤病毒存在的情况下，疱疹病毒的重复感染会导致自限性淋巴细胞增生性变化。与其他研究者报告的研究结果一起表明，DNA病毒和RNA病毒之间的相互作用可能在病毒致癌作用的自然发生中起重要作用。豚鼠为体内外研究疱疹病毒和肿瘤病毒的相互作用提供了一个有趣的动物模型。
