豚鼠疱疹病毒与肿瘤病毒之间的相互作用：体外和体内研究
The interaction between herpesvirus and oncornavirus of guineapigs: in vitro and in vivo studies.
作者信息
Fong C K, Hsiung G D
出版信息
IARC Sci Publ (1971). 1978(24 Pt 2):981-9.
In vitro, cultured guineapig doubly infected with both guineapig herpesvirus (GPHLV) and guineapig oncornavirus (GPOV) revealed pseudotype virus particles with oncornavirus morphology coated with GPHLV antigen as detected by immunoferritin electron microscopy. In vivo, infection of Hartley guineapigs with both GPHLV and GPOV induced hyperplasia in lymph-nodes in a higher percentage of animals than in those that received only one virus type. In addition, experimental GPHLV infection of strain 2 guineapigs caused some delay in the development of L2C leukaemia in inoculated animals.
在体外，用豚鼠疱疹病毒（GPHLV）和豚鼠肿瘤病毒（GPOV）双重感染培养的豚鼠，通过免疫铁蛋白电子显微镜检测发现，具有肿瘤病毒形态的假型病毒颗粒被GPHLV抗原包裹。在体内，用GPHLV和GPOV同时感染哈特利豚鼠，与仅接受一种病毒类型感染的动物相比，诱导更多动物出现淋巴结增生。此外，对2型豚鼠进行实验性GPHLV感染，对接种动物的L2C白血病发展造成了一定延迟。
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