Fliegner-Baia M, Keller J, Layer P
Medizinische Klinik, Stadtspital Triemli, Zürich, Schweiz.
MMW Fortschr Med. 2002 Oct 17;144(42):28-33.
Its high prevalence, chronic course, sometimes very troubling symptoms and rather limited therapeutic options, make the irritable bowel syndrome (IBS) one of the most common conditions seen by the family doctor, internist and gastroenterologist. IBS is characterized by abdominal pain accompanied by altered bowel movements and a facultative association with abdominal distension. IBS runs a chronic recurrent course punctuated by relatively symptom-free phases, and an overall good prognosis for survival (quoad vitam). Visceral hypersensitivity, altered gastrointestinal motility, psychosocial factors, and neurotransmitter imbalance are under discussion as underlying pathophysiology. An orienting medical history, clinical examination and exclusion of such alarm symptoms as weight loss, general debility and rectal bleeding, must be followed by a rational choice of further diagnostic measures.
肠易激综合征（IBS）患病率高、病程慢性化、有时症状极为困扰人且治疗选择相当有限，使其成为家庭医生、内科医生和胃肠病学家最常接诊的病症之一。IBS的特征是腹痛伴排便习惯改变，且可能伴有腹胀。IBS呈慢性复发性病程，期间有相对无症状期，总体生存预后良好（就生命而言）。内脏高敏感性、胃肠动力改变、心理社会因素以及神经递质失衡被认为是潜在的病理生理学机制。在进行定向病史采集、临床检查并排除体重减轻、全身虚弱和直肠出血等警示症状后，必须合理选择进一步的诊断措施。
