Ciancarelli I, Tozzi-Ciancarelli M G, Di Massimo C, Marini C, Carolei A
Department of Neurology and Laboratory of Applied Physiology, University of L'Aquila, Italy.
Cephalalgia. 2003 Feb;23(1):39-42. doi: 10.1046/j.1468-2982.2003.00447.x.
Enhanced endothelium nitric oxide (NO) and superoxide anion release may cause migraine through related cerebral blood flow changes. Thirty subjects suffering from migraine with and without aura and 20 healthy controls were investigated. Urine samples collected for 24 h during and after the migraine attack, and during the headache-free period, were assayed for urinary NO stable metabolites (NOx) and thiobarbituric acid reactive substances (TBARS). During the headache-free period urinary NOx and TBARS levels were higher in migraine sufferers than in controls (NOx 0.77 +/- 0.14 vs. 0.28 +/- 0.15 mmol/mmol creatinine, P < 0.05; TBARS 0.40 +/- 0.19 vs. 0.26 +/- 0.13 micro mol/mol creatinine, P < 0.05). Also, NOx excretion was higher during the headache-free period than during or after the migraine attack (P < 0.05). Urinary TBARS were increased during the attack with respect to the headache-free period (P < 0.05). No differences were observed in the same parameters between sufferers of migraine with and without aura. Urinary NOx and TBARS might be promising as markers of their systemic levels to evaluate the increased vulnerability to oxidative stress in migraine sufferers.
内皮一氧化氮（NO）和超氧阴离子释放增强可能通过相关脑血流变化导致偏头痛。对30名有先兆和无先兆偏头痛患者及20名健康对照者进行了研究。在偏头痛发作期间及之后以及无头痛期间收集24小时尿液样本，检测尿中NO稳定代谢产物（NOx）和硫代巴比妥酸反应性物质（TBARS）。在无头痛期间，偏头痛患者尿中NOx和TBARS水平高于对照组（NOx：0.77±0.14 vs. 0.28±0.15 mmol/mmol肌酐，P<0.05；TBARS：0.40±0.19 vs. 0.26±0.13 μmol/mol肌酐，P<0.05）。此外，无头痛期间的NOx排泄高于偏头痛发作期间或之后（P<0.05）。与无头痛期间相比，发作期间尿中TBARS增加（P<0.05）。有先兆和无先兆偏头痛患者在相同参数上未观察到差异。尿中NOx和TBARS有望作为全身水平的标志物，用于评估偏头痛患者氧化应激易感性增加的情况。
