Caimi Gregorio, Lo Presti Rosalia, Montana Maria, Noto Davide, Canino Baldassare, Averna Maurizio R, Hopps Eugenia
Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del Vespro 129, 90100 Palermo, Italy.
Oxid Med Cell Longev. 2014;2014:824756. doi: 10.1155/2014/824756. Epub 2014 Jun 2.
Our aim was to evaluate lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), nitric oxide metabolites (nitrite + nitrate) expressed as NOx, and TBARS/NOx ratio in a group of subjects with metabolic syndrome (MS). In this regard we enrolled 106 subjects with MS defined according to the IDF criteria, subsequently subdivided into diabetic (DMS) and nondiabetic (NDMS) and also into subjects with a low triglycerides/HDL-cholesterol (TG/HDL-C) index or with a high TG/HDL-C index. In the entire group and in the four subgroups of MS subjects we found an increase in TBARS and NOx levels and a decrease in TBARS/NOx ratio in comparison with normal controls. Regarding all these parameters no statistical difference between DMS and NDMS was evident, but a significant increase in NOx was present in subjects with a high TG/HDL-C index in comparison with those with a low index. In MS subjects we also found a negative correlation between TBARS/NO x ratio and TG/HDL-C index. Considering the hyperactivity of the inducible NO synthase in MS, these data confirm the altered redox and inflammatory status that characterizes the MS and suggest a link between lipid peroxidation, inflammation, and insulin resistance, evaluated as TG/HDL-C index.
我们的目的是评估一组代谢综合征（MS）患者的脂质过氧化情况（以硫代巴比妥酸反应性物质（TBARS）表示）、一氧化氮代谢产物（以亚硝酸盐+硝酸盐表示的NOx）以及TBARS/NOx比值。在这方面，我们纳入了106名根据国际糖尿病联盟（IDF）标准定义的MS患者，随后将其分为糖尿病组（DMS）和非糖尿病组（NDMS），并进一步分为甘油三酯/高密度脂蛋白胆固醇（TG/HDL-C）指数低的患者和TG/HDL-C指数高的患者。与正常对照组相比，在整个MS患者组及其四个亚组中，我们发现TBARS和NOx水平升高，TBARS/NOx比值降低。关于所有这些参数，DMS和NDMS之间没有明显的统计学差异，但与TG/HDL-C指数低的患者相比，TG/HDL-C指数高的患者中NOx显著升高。在MS患者中，我们还发现TBARS/NOx比值与TG/HDL-C指数之间呈负相关。考虑到MS中诱导型一氧化氮合酶的高活性，这些数据证实了MS所特有的氧化还原和炎症状态的改变，并提示脂质过氧化、炎症与作为TG/HDL-C指数评估的胰岛素抵抗之间存在联系。
