Bowe J, Li X F, Sugden D, Katzenellenbogen J A, Katzenellenbogen B S, O'Byrne K T
Centre for Reproduction, Endocrinology and Diabetes, King's College London, UK.
J Neuroendocrinol. 2003 Feb;15(2):105-8. doi: 10.1046/j.1365-2826.2003.00991.x.
Phytoestrogens can produce inhibitory effects on gonadotropin secretion in both animals and humans, although little is known about the mechanisms and the role of direct action on oestrogen receptors (ER) in this process. We examined the effect of coumestrol, alone and combined with ER antagonists, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 cells. Coumestrol was found to have an inhibitory effect compared to controls, which was blocked by R,R-THC, a selective ER beta antagonist. These results suggest that ER beta is involved in the suppression of GnRH mRNA expression by coumestrol.
植物雌激素可对动物和人类的促性腺激素分泌产生抑制作用，尽管在此过程中，关于其作用机制以及对雌激素受体（ER）直接作用的作用尚知之甚少。我们研究了香豆雌酚单独以及与ER拮抗剂联合使用时，对GT1-7细胞中促性腺激素释放激素（GnRH）mRNA表达的影响。与对照组相比，发现香豆雌酚具有抑制作用，而这种作用被选择性ERβ拮抗剂R,R-THC所阻断。这些结果表明，ERβ参与了香豆雌酚对GnRH mRNA表达的抑制作用。
