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肝内植入胰岛对大鼠肝功能的影响。

Effect of intrahepatically implanted islets of Langerhans on hepatic function in the rat.

作者信息

Amamoo D G, Woods J E, Holley K E

出版信息

Mayo Clin Proc. 1975 Jul;50(7):416-9.

PMID:125372
Abstract

Diabetes mellitus is satisfactorily controlled in the rat by hepatic implantation of isolated, isologous pancreatic islets. The transplanted islets appear to be viable for at least 6 months after implantation, and hepatic function studies (serum bilirubin, alkaline phosphatase, glutamic-oxalacetic transaminase, prothrombin time) and microscopic examination indicate that they do not interfere with hepatic function.

摘要

通过将分离的同基因胰岛植入大鼠肝脏,可使糖尿病得到满意控制。移植的胰岛在植入后至少6个月似乎仍有活力,肝功能研究(血清胆红素、碱性磷酸酶、谷草转氨酶、凝血酶原时间)及显微镜检查表明,它们不会干扰肝功能。

相似文献

1
Effect of intrahepatically implanted islets of Langerhans on hepatic function in the rat.肝内植入胰岛对大鼠肝功能的影响。
Mayo Clin Proc. 1975 Jul;50(7):416-9.
2
Preliminary experience with pancreatic islet-cell implantation.胰岛细胞植入的初步经验。
Mayo Clin Proc. 1974 May;49(5):289-92.
3
Pancreatic islet isografts, allografts, and xenografts: comparison of morphology and function.胰岛同基因移植、同种异体移植和异种移植:形态学与功能比较
Surgery. 1976 Feb;79(02):144-51.
4
Normalization of the altered liver function tests after islet transplantation in diabetic rats.糖尿病大鼠胰岛移植后肝功能检查指标异常的恢复正常
Diabete Metab. 1990 Jul-Aug;16(4):284-9.
5
[Histological and immunohistochemical investigations on the transplanted isolated islets of Langerhans in diabetic rats (author's transl)].
Acta Histochem. 1977;58(1):85-99.
6
Transplantation of islets of Langerhans.
Arch Pathol. 1975 Aug;99(8):401-2.
7
[Intrahepatic implantation of pancreatic endocrine islets. Its efficacy in the treatment of experimental diabetes].
Chirurgie. 1976 Mar;102(4):256-66.
8
Orthotopic partial liver transplantation in the rat: a model of 70% hepatectomy and reduced size liver transplantation.大鼠原位部分肝移植:70%肝切除及减体积肝移植模型
Transplantation. 1993 Oct;56(4):1041-3.
9
Intrahepatic transplantation of pancreatic islets in the rat.大鼠肝内胰岛移植
Horm Metab Res. 1977 Jan;9(1):40-6. doi: 10.1055/s-0028-1093581.
10
Long-term metabolic and immunological considerations in transplantation of pancreatic islets.胰岛移植中的长期代谢与免疫学考量
J Surg Res. 1974 Jun;16(6):575-81. doi: 10.1016/0022-4804(74)90088-2.

引用本文的文献

1
Gene therapy for diabetes mellitus in rats by hepatic expression of insulin.通过肝脏表达胰岛素对大鼠糖尿病进行基因治疗。
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3293-7. doi: 10.1073/pnas.92.8.3293.
2
Pancreas and islet transplantation. I. Experimental studies.胰腺和胰岛移植。I. 实验研究。
Diabetologia. 1981 Mar;20(3):161-85. doi: 10.1007/BF00252624.
3
Transplantation of isologous islets of Langerhans in diabetic rats. Long-term immunohistochemical results.
Acta Diabetol Lat. 1977 Sep-Dec;14(5-6):199-210. doi: 10.1007/BF02580968.
4
Pancreas and islet transplantation.胰腺和胰岛移植。
World J Surg. 1977 Mar;2(1):185-95. doi: 10.1007/BF01665079.
5
Autotransplantation of pancreatic fragments to the portal vein and spleen of totally pancreatectomized dogs: a comparative evaluation.将胰腺碎片自体移植至全胰切除犬的门静脉和脾脏:一项比较评估。
Ann Surg. 1978 Jan;187(1):79-86. doi: 10.1097/00000658-197801000-00015.
6
The fate of transplanted pancreatic islets in the rat.大鼠移植胰岛的命运
Am J Pathol. 1979 Jan;94(1):85-95.
7
Transplantation of preserved pancreatic islets into the portal vein of rats.将保存的胰岛移植到大鼠门静脉中。
Jpn J Surg. 1978 Jun;8(2):152-8. doi: 10.1007/BF02469371.