Franklin W A, Schulak J A, Reckard C R
Am J Pathol. 1979 Jan;94(1):85-95.
Syngeneic pancreatic islets transplanted into the liver or the spleen reverse streptozotocin-induced diabetes in the rat, but allogeneic islets function only briefly and are rejected. Shortly after transplantation, thrombi often form around transplanted tissue, particularly around nonislet tissue that contaminates islet preparations. These thrombi are a source of transient liver injury in recipients of intrahepatic grafts. A few days after transplantation, syngeneic islets injected into the portal vein are found at the periphery of portal tracts in direct contact with periportal hepatocytes, some of which become hypertrophied. Isografts remain situated in the portal tracts for prolonged periods without adverse effect on the surrounding liver. In contrast, allogeneic islets injected into the portal vein are infiltrated by small lymphocytes within 2 days of transplantation and are rapidly destroyed by the host. Syngeneic islets injected into the splenic pulp localize in the sinusoids and, 1 month or more after transplantation, are often surrounded by connective tissue or local collections of hemosiderin-laden macrophages. Allogeneic islets injected into the spleen are rejected with the same intensity and at approximately the same rate as allogeneic islets injected into the portal vein. Transplant rejection leaves no significant lasting morphologic effect on the host liver or spleen.
将同基因胰岛移植到肝脏或脾脏中可逆转链脲佐菌素诱导的大鼠糖尿病，但异基因胰岛仅能短暂发挥功能并被排斥。移植后不久，血栓常围绕移植组织形成，尤其是在污染胰岛制剂的非胰岛组织周围。这些血栓是肝内移植受体短暂性肝损伤的一个来源。移植几天后，注入门静脉的同基因胰岛位于门管区周边，与门周肝细胞直接接触，其中一些肝细胞会肥大。同基因移植胰岛可长时间位于门管区，而对周围肝脏无不良影响。相比之下，注入门静脉的异基因胰岛在移植后2天内就会被小淋巴细胞浸润，并迅速被宿主破坏。注入脾髓的同基因胰岛定位于血窦，移植1个月或更长时间后，常被结缔组织或含铁血黄素巨噬细胞局部聚集所包围。注入脾脏的异基因胰岛与注入门静脉的异基因胰岛以相同强度、大致相同速率被排斥。移植排斥对宿主肝脏或脾脏没有显著的持久形态学影响。
