Zayat Leonardo, Calero Cecilia, Alborés Pablo, Baraldo Luis, Etchenique Roberto
Departamento de Química Inorgánica, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, AR1428EHA Buenos Aires, Argentina.
J Am Chem Soc. 2003 Jan 29;125(4):882-3. doi: 10.1021/ja0278943.
A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed.
提出了一种构建笼形化合物的新策略。该方法基于配位化合物中金属-配体键的异裂光解。一种含有神经化合物4-氨基吡啶（4AP）的钌多吡啶配合物被用作光触发剂的核心。通过可见光（>480 nm）照射释放生物分子。释放出的4AP通过阻断水蛭神经元的钾通道来促进其激活。讨论了该方法的合成、表征及其固有优点。
