Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
Photochem Photobiol Sci. 2013 Sep;12(9):1565-70. doi: 10.1039/c3pp25248e.
We have devised a new caged GABA based on ruthenium bipyridyl coordination chemistry. This phototrigger delivers GABA upon irradiation with wavelengths up to 532 nm undergoing heterolytic photocleavage, in a clean and very fast (a few nanoseconds) photoreaction. With an absorptivity coefficient ε(MAX) = 5300 M(-1) cm(-1) at 447 nm and a quantum efficiency φ ~ 0.09, RuBiGABA-2 is among the most active caged-GABAs, especially at long wavelengths. This highly hydrophilic caged GABA can be synthesized in a simple one-pot reaction. The synthesis, chemical characterization and photochemical properties are presented. Finally, the usefulness of this caged compound is demonstrated by photodelivering free GABA on leech motoneurons.
我们设计了一种基于钌联吡啶配位化学的新型笼状 GABA。这种光触发物在波长高达 532nm 的光照射下通过异裂光解释放 GABA，反应干净且非常快速（几纳秒）。RuBiGABA-2 的消光系数 ε(MAX) 在 447nm 时为 5300M(-1)cm(-1)，量子效率 φ~0.09，是最活跃的笼状 GABA 之一，尤其是在长波长下。这种高度亲水的笼状 GABA 可以通过简单的一锅反应合成。本文介绍了其合成、化学表征和光化学性质。最后，通过在螯合化合物上光解释放游离 GABA 来证明这种笼状化合物的有用性。
