Kubo Isao, Fujita Ken ichi, Nihei Ken ichi, Masuoka Noriyoshi
Department of Environmental Science, Policy and Management, University of California, CA 94720-3112, Berkeley, USA.
Bioorg Med Chem. 2003 Feb 20;11(4):573-80. doi: 10.1016/s0968-0896(02)00436-4.
Dodecyl (C(12)) gallate (3,4,5-trihydroxybenzoate) (1) was found to possess antibacterial activity specifically against Gram-positive bacteria, in addition to its potent antioxidant activity. The time-kill curve study indicates that this amphipathic gallate exhibits bactericidal activity against methicillin resistant Staphylococcus aureus (MRSA) strains. Dodecyl (lauryl) gallate inhibited oxygen consumption in whole cells and oxidation of NADH in membrane preparation. The antibacterial activity of this gallate comes in part from its ability to inhibit the membrane respiratory chain. As far as alkyl gallates are concerned, their antimicrobial spectra and potency depend in part on the hydrophobic portion of the molecule.
没食子酸十二酯（C(12)）（3,4,5-三羟基苯甲酸酯）（1）除具有强大的抗氧化活性外，还被发现对革兰氏阳性菌具有特异性抗菌活性。时间-杀菌曲线研究表明，这种两亲性没食子酸酯对耐甲氧西林金黄色葡萄球菌（MRSA）菌株具有杀菌活性。没食子酸十二酯（月桂酯）抑制全细胞中的氧气消耗以及膜制剂中NADH的氧化。这种没食子酸酯的抗菌活性部分源于其抑制膜呼吸链的能力。就烷基没食子酸酯而言，它们的抗菌谱和效力部分取决于分子的疏水部分。
