Kahkeshani Niloofar, Farzaei Fatemeh, Fotouhi Maryam, Alavi Seyedeh Shaghayegh, Bahramsoltani Roodabeh, Naseri Rozita, Momtaz Saeideh, Abbasabadi Zahra, Rahimi Roja, Farzaei Mohammad Hosein, Bishayee Anupam
Department of Pharmacognosy, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
PhytoPharmacology Interest Group, Universal Scientific Education and Research Network, Tehran, Iran.
Iran J Basic Med Sci. 2019 Mar;22(3):225-237. doi: 10.22038/ijbms.2019.32806.7897.
Gallic acid is a natural phenolic compound found in several fruits and medicinal plants. It is reported to have several health-promoting effects. This review aims to summarize the pharmacological and biological activities of gallic acid and animal models to depict the pharmacological status of this compound for future studies.
All relevant papers in the English language were collected up to June 2018. The keywords of gallic acid, antioxidant, anticancer, antimicrobial, gastrointestinal-, cardiovascular-, metabolic-, neuropsychological-, and miscellaneous- diseases were searched in Google Scholar, PubMed, and Scopus.
Several beneficial effects are reported for gallic acid, including antioxidant, anti-inflammatory, and antineoplastic properties. This compound has been reported to have therapeutic activities in gastrointestinal, neuropsychological, metabolic, and cardiovascular disorders.
Current evidence confirms the pharmacological and therapeutic interventions of gallic acid in multiple health complications; however, available data are limited to just cellular and animal studies. Future investigations are essential to further define the safety and therapeutic efficacy of gallic acid in humans.
没食子酸是一种存在于多种水果和药用植物中的天然酚类化合物。据报道，它具有多种促进健康的作用。本综述旨在总结没食子酸的药理和生物学活性以及动物模型，以描述该化合物的药理状况，为未来的研究提供参考。
截至2018年6月，收集了所有英文相关文献。在谷歌学术、PubMed和Scopus中搜索了没食子酸、抗氧化剂、抗癌、抗菌、胃肠道疾病、心血管疾病、代谢疾病、神经心理疾病及其他杂项疾病等关键词。
没食子酸具有多种有益作用，包括抗氧化、抗炎和抗肿瘤特性。据报道，该化合物在胃肠道、神经心理、代谢和心血管疾病方面具有治疗活性。
目前的证据证实了没食子酸在多种健康并发症中的药理和治疗干预作用；然而，现有数据仅限于细胞和动物研究。未来的研究对于进一步确定没食子酸在人体中的安全性和治疗效果至关重要。
