Wang H, Luo J, Su W, He Q, Huang X
Department of Stomatology, Third People's Hospital of Chengdu.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2001 Feb;19(1):41-2, 51.
The study was designed to evaluate the antiseptic efficacy of Tinidazole stilus against periodontal pathogen.
A total of 41 patients with periodontitis were included in this study. 26 of them were treated by Tindazole stilus and other 15 cases were treated by metronidazole stilus as controls. The prevalence of subgingival bacteria from both group were examined.
The eliminate rates for Black pigmented anaerobic rod (Porphyromonas gingivalis, Prevotella intermedius, Prevotella melaninogenicus), Fusobacteriums, Prevotella oris, Prevotella oralis, Eubacterium and Actinomyces were 95.8% 94.1%, 83.3% and 76.5%. The anti-bacterial efficiency of Tinidazole against periodontal pathogen was significantly higher than that of metronidazole (P < 0.05).
It appears to be effective to use Tinidazole stilus as local application against periodontal pathogens.
本研究旨在评估替硝唑棒剂对牙周病原菌的抗菌效果。
本研究共纳入41例牙周炎患者。其中26例采用替硝唑棒剂治疗，另外15例采用甲硝唑棒剂作为对照进行治疗。检测两组龈下细菌的患病率。
黑色色素厌氧菌（牙龈卟啉单胞菌、中间普氏菌、产黑色素普氏菌）、梭杆菌属、口腔普氏菌、口腔普氏菌、真杆菌属和放线菌属的清除率分别为95.8%、94.1%、83.3%和76.5%。替硝唑对牙周病原菌的抗菌效率显著高于甲硝唑（P<0.05）。
局部应用替硝唑棒剂对抗牙周病原菌似乎是有效的。
