Järbe T U, Johansson J O, Henriksson B G
Psychopharmacologia. 1975 Apr 30;42(1):33-9. doi: 10.1007/BF00428822.
Choice responding in a T-shaped maze has been made contingent upon whether or not rats experienced certain drug effects. The drug discriminative cues used in the present state-dependent (StD) model were those of phencyclidine (PCP) and ditran. The specificity of these cues and their possible drug inhibition and antagonism was studied. It was found that the lower the training dose used the slower the appearance of the drug discriminative formation. Transfer testings with ketamine and cyclohexamine showed that they were interchangeable with PCP. The order of their relative potency was: cyclohexamine greater than PCP greater than ketamine. Atropine transferred to ditran. Administration of compounds not structurally related to the training drugs did not show transfer. Pretreatment with parachlorphenylalanine (p-CPA) or tetrabenazine (TBZ) plus imipramine did not indicate inhibition or antagonism in PCP trained rats. Tacrine (THA) and especially physostigmine effectively antagonized the ditran-induced cues. Yohimbine and neostigmine did not.
在T形迷宫中的选择反应取决于大鼠是否经历过某些药物效应。当前状态依赖（StD）模型中使用的药物辨别线索是苯环己哌啶（PCP）和地曲哌嗪的线索。研究了这些线索的特异性及其可能的药物抑制和拮抗作用。发现训练剂量越低，药物辨别形成的出现就越慢。用氯胺酮和环己胺进行的转移测试表明，它们可与PCP互换。它们相对效力的顺序为：环己胺大于PCP大于氯胺酮。阿托品可转移到地曲哌嗪。给予与训练药物结构无关的化合物未显示出转移。用对氯苯丙氨酸（p-CPA）或丁苯那嗪（TBZ）加丙咪嗪预处理在PCP训练的大鼠中未显示出抑制或拮抗作用。他克林（THA），尤其是毒扁豆碱有效地拮抗了地曲哌嗪诱导的线索。育亨宾和新斯的明则不能。
