Johansson J O, Järbe T U
Arch Int Pharmacodyn Ther. 1976 Jan;219(1):97-102.
Rats, trained to respond differentially in a T-maze contingent upon the presence or absence of physostigmine (0.50 mg/kg), showed a reversal of drug responding when physostigmine (0.50 mg/kg) was given simultaneously with the anticholinergic ditran (dose range: 0.80-3.20 mg/kg). Testing the quaternary anticholinesterase neostigmine (0.50 mg/kg) resulted in no drug responding which indicates a central site of action for the physostigmine discrimination.
训练大鼠在T型迷宫中根据是否存在毒扁豆碱（0.50毫克/千克）做出不同反应，当毒扁豆碱（0.50毫克/千克）与抗胆碱能药物地卓西平（剂量范围：0.80 - 3.20毫克/千克）同时给药时，大鼠的药物反应出现逆转。测试季铵抗胆碱酯酶新斯的明（0.50毫克/千克）时未出现药物反应，这表明毒扁豆碱辨别存在中枢作用位点。
